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KMID : 1149220080160020101
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Korean Journal of Oriental Medical Prescription
2008 Volume.16 No. 2 p.101 ~ p.114
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The Experimental study of Hwagae-san on Anti-Inflammatory Effect
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No Woon-Serb
Shin Jo-Young
Lee Si-Hyeong
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Abstract
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Objective : The purpose of this study was to investigate the anti-inflammatory effects of Hwagae-san extract(HGSE) on the peritoneal macrophage.
Methods : To evaluate anti-inflammatory effects of HGSE, We measured cytokines(interleukin-6; IL-6, interleukin-12; IL-12, tumor necrosis factor-; TNF-) and nitric oxide(NO) production in lipopolysaccharide(LPS)-induced macrophages. Furthermore, We examined molecular mechanism using western blot and also LPS-induced endotoxin shock.
Results : 1. HGSE did not have any cytotoxic effect in the peritoneal macrophages. 2. HGSE reduced LPS-induced IL-6, TNF-, IL-12 and NO production in peritoneal macrophages. 3. HGSE inhibited the activation of extracelluar signal-regulated kinase(ERK), C-Jun NH2-terminal kinase(JNK) but not of p38, degradation of IkB- in the LPS-stimulated peritoneal macrophages. 4. HGSE inhibited the production of TNF-, IL-6 and IL-12 in serum after LPS injection.
Conclusion : These results suggest that HGSE may inhibit the production of TNF-, IL-6, and IL-12 through inhibition of ERK and JNK activation, and that HGSE may be beneficial for inflammatory diseases.
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KEYWORD
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Hwagae-san, Anti-Inflammatory Effect, Oriental medicine
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